I’ve quoted some of this before, but it was buried in a long post and it’s worth quoting at greater length and on its own. It succinctly lays out his views on several issues relevant to present-day discussions of replication in science. Specifically, Popper makes clear that (1) scientists should replicate their own experiments; (2) scientists should be able to instruct other experts how to reproduce their experiments and get the same results; and (3) establishing the reproducibility of experiments (“direct replication” in the parlance of our times) is a necessary precursor for all the other things you do to construct and test theories.
Kant was perhaps the first to realize that the objectivity of scientific statements is closely connected with the construction of theories — with the use of hypotheses and universal statements. Only when certain events recur in accordance with rules or regularities, as is the case with repeatable experiments, can our observations be tested — in principle — by anyone. We do not take even our own observations quite seriously, or accept them as scientific observations, until we have repeated and tested them. Only by such repetitions can we convince ourselves that we are not dealing with a mere isolated ‘coincidence’, but with events which, on account of their regularity and reproducibility, are in principle inter-subjectively testable.
Every experimental physicist knows those surprising and inexplicable apparent ‘effects’ which in his laboratory can perhaps even be reproduced for some time, but which finally disappear without trace. Of course, no physicist would say in such a case that he had made a scientific discovery (though he might try to rearrange his experiments so as to make the effect reproducible). Indeed the scientifically significant physical effect may be defined as that which can be regularly reproduced by anyone who carries out the appropriate experiment in the way prescribed. No serious physicist would offer for publication, as a scientific discovery, any such ‘occult effect,’ as I propose to call it — one for whose reproduction he could give no instructions. The ‘discovery’ would be only too soon rejected as chimerical, simply because attempts to test it would lead to negative results. (It follows that any controversy over the question whether events which are in principle unrepeatable and unique ever do occur cannot be decided by science: it would be a metaphysical controversy.)
– Karl Popper (1959/2002), The Logic of Scientific Discovery, pp. 23-24.